General Information

  • ID:  hor000305
  • Uniprot ID:  A0A2P8YBG2
  • Protein name:  BLAST-2
  • Gene name:  ALLS
  • Organism:  Blattella germanica (German cockroach) (Blatta germanica)
  • Family:  Allatostatin family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Blattella (genus), Blattellinae (subfamily), Ectobiidae (family), Blaberoidea (superfamily), Blattodea (order), Dictyoptera (superorder), Polyneoptera (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  NA
  • GO CC:  NA

Sequence Information

  • Sequence:  DRLYSFGL
  • Length:  8
  • Propeptide:  MLIATFFNEKPMPGPRTCYSLQAALVLSLLLKLSSSAFATTTSAGTHAVQEESSAGGGAEILPRLEELADNSELDLVKRLYDFGLGKRAYSYVSEYKRLPVYNFGLGKRSKMYGFGLGKRAGSDGRLYSFGLGKRDYDDYYGDDDEEDHQTSADEDIEDADSVDLMDKRDRLYSFGLGKRARPYSFGLGKRAPSSAQRLYGFGLGKRALYSFGLGKRAGGRLYSFGLGKRPVNSGRQSGSRFNFGLGKRSDDFDI
  • Signal peptide:  MLIATFFNEKPMPGPRTCYSLQAALVLSLLLKLSSSAFA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Inhibited in vitro juvenile hormone production by corpora allata from virgin females of B. germanica.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-A0A2P8YBG2-F1(AlphaFold_DB_ID)
  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
  •    hor000305_AF2.pdbhor000305_ESM.pdb

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Physical Information

Mass: 109513 Formula: C45H67N11O13
Absent amino acids: ACEHIKMNPQTVW Common amino acids: L
pI: 6.34 Basic residues: 1
Polar residues: 3 Hydrophobic residues: 3
Hydrophobicity: -1.25 Boman Index: -1342
Half-Life: 1.1 hour Half-Life Yeast: 3 min
Half-Life E.Coli: >10 hour Aliphatic Index 97.5
Instability Index: -67.5 Extinction Coefficient cystines: 1490
Absorbance 280nm: 212.86

Literature

  • PubMed ID:  7846299
  • Title:  Allatostatic Neuropeptides From the Cockroach Blattella Germanica (L.) (Dictyoptera, Blattellidae). Identification, Immunolocalization and Activity